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Strawberry Compound a Key to Good Memory By Dr. Mercola

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Ask several people what their favorite fruit is, and a good number of them will say strawberries. But aside from being luscious and one of the most fragrant, colorful essences of summer, this fruit contains a powerful compound that can make a remarkable difference in treating, improving and protecting against many disorders and diseases in your body.

This somewhat obscure compound, fisetin, has been shown to decrease pain, prevent toxicity, maintain energy and improve your energy levels on a macro level, translating to more specific benefits in your overall health. Forbes noted:

“Never heard of fisetin? That’s because it was only identified a little more than a decade ago when scientists isolated plant flavonols with the ability to protect brain cells from degeneration. Like the similar flavonol quercetin, it’s a sirtuin-activating compound that mimics many of the natural effects of calorie restriction, a well-studied anti-aging strategy.”1

Also the coloring agent, fisetin is also a flavanol, also found in persimmons, apples, mangoes, grapes, cucumbers and onions, but strawberries contain the most by far, according to a 2013 study.2 A Japanese study reported that the highest concentration of fisetin was found in strawberries (160 μg/g, or microgram/gram) followed by apple (26.9 μg/g) and persimmon (10.5 μg/g).3

While fisetin has antioxidant properties, which can help curb cell damage caused by free radicals, one of the most dramatic ways it impacts your health is targeted toward your brain, as studies indicate it can help prevent Alzheimer’s and other age-related neurodegenerative diseases.

According to Forbes, Pamela Maher, senior staff scientist at the Cellular Neurobiology Laboratory at the Salk Cellular Neurobiology Laboratory, called fisetin a “novel neuroprotective and cognitione-enhancing molecule.”4She and her colleagues spent 10 years conducting studies on fisetin to find additional brain benefits as well as benefits for other areas of the body.

According to the study5, some of the ways fisetin impacts your brain health is that it helps protect against damage due to injury and degeneration from aging, and also improves your memory while working with other compounds, activating nerve cells and increasing the defense systems throughout your brain and body.

Fisetin Studies Related to Brain Aging

One of Maher’s studies in 2014 focused on memory loss in mice due to familial Alzheimer’s, which is a type that accounts for only 3 percent of cases. The newest study examined possible fisetin advantages on sporadic Alzheimer’s disease, the most common type associated with age.6 Scientists used mice that had been “genetically engineered to age prematurely, resulting in a mouse model of sporadic Alzheimer’s disease,” Medical News Today said:

“When the prematurely aging mice were 3 months old, they were divided into two groups. One group was fed a dose of fisetin with their food every day for 7 months, until they reached the age of 10 months. The other group did not receive the compound.

The team explains that at 10 months of age, the physical and cognitive states of the mice were the equivalent to those of 2-year-old mice. All rodents were subject to cognitive and behavioral tests throughout the study, and the researchers also assessed the mice for levels of markers linked to stress and inflammation.”7

Assessment then revealed that the 10-month-old mice not given fisetin had more markers linked to stress and inflammation, and performed “significantly worse” in cognitive testing than those given fisetin. Maher termed the differences “striking.” More specifically, two neurons, astrocytes and microglia, usually considered anti-inflammatory, were actually promoting inflammation in the brains of the no-fisetin mice.

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